Monoclonal Antibody As Anti Cancer Agents
Abstract
ABSTRACT The recent clinical and commercial success of anticancer antibodies such as rituximab and trastuzumab has created great interest in antibody-based therapeutics for hematopoietic malignant neoplasms and solid tumors. In the recent years of immunologic research, we are witnessing development in the fields of antigen screening and protein engineering in order to create specific anticancer remedies. The developments in the field of recombinant DNA, protein engineering and cancer biology have let us gain insight into many cancer-related mechanisms. Moreover, novel techniques have facilitated tools allowing unique distinction between malignantly transformed cells, and regular ones. This understanding has paved the way for the rational design of a new age of pharmaceuticals: monoclonal antibodies and their fragments. Antibodies can select antigens on both a specific and a high-affinity account, and further implementation of these qualities is used to target cancer cells by specifically identifying exogenous antigens of cancer cell populations. The structure of the antibody provides plasticity resonating from its functional sites. This review will spot the light on some of the novel antibodies and antibody-based approaches that are being currently developed for the new generation of anticancer agents. Key words: Antibody, cancer immunotherapy, tumor antigens, anti tumor mechanisms, targeted therapy, antibody fusions.Downloads
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How to Cite
Sahil, K. (2011). Monoclonal Antibody As Anti Cancer Agents. International Journal of Pharmaceutical & Biological Archive, 2(5). Retrieved from http://www.ijpba.info/index.php/ijpba/article/view/399
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This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.