“Synthesis, Characterization, and Antipsychotic Evaluation of Some Aryl Piperazine Congeners”

Abstract

In this proposal research work aryl piperazine derivatives will be synthesised because aryl piperazine currently the most important building blocks in drug discovery with a high number of positive hits encountered in biological screens of this heterocyclic and its congeners. A series N-(4-(benzo[d]thiazol-2-yl)phenyl)-2-[4- (arylsubstituted)piperazines-1-yl]acetamide and N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide will be synthesized with different aryl piperzine substituents and their characterization such as melting point determination and Thin layer chromatography (TLC) also performed. After that pharmacological evaluation will be done for synthesized compounds. In pharmacological evaluation the antipsychotic activity determined by behaviour symptoms, Inhibition of 5-hydoxytryptophan (5-HTP) induced head twitches behavior and Induction of catalepsy.