Formulation Development and Characterization of Topical Gel for Psoriasis

Formulation Development and Characterization of Topical Gel for Psoriasis

Authors

  • Vrunal V. More

DOI:

https://doi.org/10.22377/ijpba.v10i01.1749

Abstract

The purpose of this research work was to develop and characterize a tacrolimus (TAC) gel using different
polymers for the treatment of psoriasis. The physicochemical compatibility was confirmed between
TAC and other excipients by Fourier transfer infrared. Formulated gels were characterized for drug
content, viscosity, extrudability, skin irritation study, pH, in vitro diffusion study, and stability. Release
of TAC from all formulations using dialysis membrane into a phosphate buffer pH 6.8 at 37°C was
performed. Optimized batch was selected from this characterization study. Based on the data collected,
it was revealed that TAC has proven to be a promising candidate for delivery through gel in the treatment
of psoriasis.

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Published

2019-03-19

How to Cite

More, V. V. (2019). Formulation Development and Characterization of Topical Gel for Psoriasis: Formulation Development and Characterization of Topical Gel for Psoriasis. International Journal of Pharmaceutical & Biological Archive, 10(01). https://doi.org/10.22377/ijpba.v10i01.1749

Issue

Vol. 10 No. 01 (2019): International Journal of Pharmaceutical & Biological Archive

Section

Research Articles

License

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.