Abstract

The purpose of this research work was to develop and characterize a tacrolimus (TAC) gel using different
polymers for the treatment of psoriasis. The physicochemical compatibility was confirmed between
TAC and other excipients by Fourier transfer infrared. Formulated gels were characterized for drug
content, viscosity, extrudability, skin irritation study, pH, in vitro diffusion study, and stability. Release
of TAC from all formulations using dialysis membrane into a phosphate buffer pH 6.8 at 37°C was
performed. Optimized batch was selected from this characterization study. Based on the data collected,
it was revealed that TAC has proven to be a promising candidate for delivery through gel in the treatment
of psoriasis.